- Voltage-gated Ca2+ channels
in the presynaptic membrane open in response to an action potential.
- Ca2+ ions flow in.
- Synaptic vesicles fuse with presynaptic membrane of the synaptic terminal,
- Neurotransmitters diffuse across synaptic cleft and bind to
ligand-gated channels in the postsynaptic membrane.
- Ions flow in and generate a postsynaptic potential.
- Neurotransmitters release from channels, which close.