Chapter 18
: Regulation of Gene Expression
trp_regulation
Central dogma: transcribed=expression
lac_operon
Ferment; beta galactosidase converts some lac to allo; cistron=locus -> polypeptide.
lac_repressed
lacI Inhibits by making repressor; operon also has lacY, lacA
activator
Distal control elements (far from promoter); note transcription factors.
DNA transcription
: initiation complex
acetylation
NSN_Epigenetics.mp4
3:00 mice agouti gene methylated (CH3)
NOVA
QH438.5 .G456 2006
Ghost in Your Genes:
13:00 Epigenetic deletion in chromosome 15, depends on parent.
Epigenetic (ABOVE) change in gametes lead to genomic imprinting.
splicing
Troponin T muscle proteins - binds to tropomyosin to associate with actin.
euk-regulation_cytoplasm
Review 1:
says drgrade poly-A tail first.
mRNA_degradation
REVU; donot confuse miRNA w mRNA.
cytoplasmic
2008 physics Nobel: spontaneous broken
symmetry
cytoplasmic_Drosophila
21 B
Bicoid mRNA from nurse cells.
determination
MyoD (transcription factor) activates other genes, blocks cell cycle - multinucleate.
proto-oncogene
Transposable elements in ch21. ras is proto-oncogene; p53 tumor-suppressor.
p53_tumor-suppressor
Tumor-suppressor also repair DNA.
Adenovirus and p53:
colorectal_cancer
Colonoscope
removes pre-cancerous polyp
Colonoscopy
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8eSQ 1=d 2=a 3=d 4=a 5=c 6=e 7=a 8=c 9=b 10=b